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National Guideline Clearinghouse, Guidelines on Testicular Cancer
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MRI: Non-Invasive Diagnostic Tool For Diagnosing Testicular Cancer

February 22, 2010
Source: Redorbit News

Researchers have found that non-invasive magnetic resonance imaging (MRI) is a good diagnostic tool for the evaluation and staging of testicular cancer and may improve patient care by sparing some men unnecessary surgery, according to a study in the March issue of the American Journal of Roentgenology.

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Testicular Cancer Survivors May Have Hormone Deficiency

February 22, 2010
Source: HealthDay

Testosterone deficiency in young male cancer survivors often causes low energy levels and reduced quality of life, and these patients may benefit from testosterone replacement therapy, a new study suggests.

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UPDATED GUIDELINES FOR DIAGNOSIS, STAGING, AND TREATMENT OF TESTICULAR CANCER

February 4, 2010
Source: Department of Urology, Albertinen-Krankenhaus Hamburg, Hamburg.

Chronic vascular morbidity resulting form chemotherapy for testicular germ-cell cancer (TGCC) is recognized. Cardiovascular events (CVEs) occurring early during chemotherapy are less understood. We evaluated the incidence and clinical features of CVEs associated with chemotherapy of TGCC.

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Public perceptions of the harms and benefits of testicular cancer education: A qualitative study - Abstract
February 3, 2010
Source: UroToday.com Testicular Cancer Section

The value of testicular cancer (TC) education, and in particular advice on testicular self-examination (TSE), has been widely debated by health professionals. One concern centres on its potential to cause unnecessary anxiety among the target population. Views outside the health professional community about TC education's potential benefits and harms have not previously been described. The objective of this study was to investigate the range of views expressed by specific groups thought to have an interest in provision of TC education.

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Identification of spermatozoa in archived testicular cancer specimens: Implications for bench side sperm retrieval at orchiectomy - Abstract
February 2, 2010
Source: UroToday.com Testicular Cancer Section

To evaluate the patterns of spermatogenesis in the normal testicular parenchyma of primary testicular cancers and estimate the feasibility of sperm retrieval at the time of radical orchiectomy.

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Relatives of boys with sexual birth defects not at risk for testicular germ cell cancer
December 21, 2009
Source: Journal of the National Cancer Institute

Boys with the sexual birth defects known as hypospadias and cryptorchidism are at risk for developing testicular germ cell cancer, but their relatives are not, according to a new study published online December 21 in the Journal of the National Cancer Institute.

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Cisplatin-based chemotherapy linked to severe side effects in long-term survivors of testicular cancer

November 30, 2009

Source: HemOncToday

Long-term survivors of unilateral testicular cancer treated with cisplatin-based chemotherapy had more dosedependent neurological side effects and Raynaud-like phenomena, or discoloration of the fingers and toes upon exposure to cold, when compared with patients who were not treated with chemotherapy, according to the results of a follow-up study.

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Long-term effects of testicular cancer chemo seen
November 25, 2009
By Laura Bucholz courtesy of Reuters

NEW YORK (Reuters Health) - Men wondering about the long-term side effects of chemotherapy for testicular cancer may now have a road map defining likely outcomes.

A Norwegian study, published today in the Journal of the National Cancer Institute, reveals that long-term side effects vary depending on the dose of
chemotherapy given and how many cycles of chemotherapy the men received.

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Treatment not testicular cancer poses greatest risk to survivors' long-term health
October 15, 2009
Source: http://www.physorg.com

Testicular cancer survivors can face an increased risk of long-term illness, not because of the malignancy, but the highly effective treatment they receive, according to a study in the urology journal BJUI.

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Treatment not testicular cancer poses greatest risk to survivors' long-term health
October 15, 2009
Source: Physorg.com

Testicular cancer survivors can face an increased risk of long-term illness, not because of the malignancy, but the highly effective treatment they receive, according to a study in the urology journal BJUI.

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Environmental Chemicals Found In Breast Milk And High Incidence Of Testicular Cancer
September 25, 2009
Source: Science Daily

A comparison of breast milk samples from Denmark and Finland revealed a significant difference in environmental chemicals which have previously been implicated in testicular cancer or in adversely affecting development of the fetal testis in humans and animals.

This finding is published in the International Journal of Andrology.

Check with your own physician. The AAP continues to recommend breastfeeding, whenever possible.

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Time trends in the incidence of testicular cancer in childhood and young adulthood -Abstract
August 3, 2009
Source: Cancer Epidemiology Unit, University of Turin, Turin, Italy.

There has been a steep increase in the incidence of adult testicular cancer in many populations, but in spite of numerous studies, the etiology of testicular cancer remains elusive. The time trends of childhood testicular tumors are less clear and have been studied in a few populations. To further evaluate whether or not adult and childhood cancers share trend determinants and whether future adult testicular cancer incidences can be predicted through childhood testicular cancer incidences, their rates were compared.

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Second Gene Linked to Familial Testicular Cancer
June 29, 2009
Source: National Institutes of Health

Specific variations or mutations in a particular can gene raise a man’s risk of familial, or inherited, testicular germ-cell cancer, the most common form of this disease, according to new research by scientists at the National Institutes of Health. This is only the second gene to be identified that affects the risk of familial testicular cancer, and the first gene in a key biochemical pathway. The study appeared online June 23, 2009, in Cancer Research.

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Paediatric Testicular Cancer: An Updated Review of Incidence and Conditional Survival from the Surveillance, Epidemiology and End Results Database - Abstract
June 10, 2009
Source: Division of Paediatric Urology, University of minnesota, Minneapolis, MN

To determine, using the Surveillance, Epidemiology, and End Results (SEER) population-based database, the epidemiological variables and update the understanding of testicular tumours in children, as knowledge of their incidence and survival is predicated upon multi-institutional cooperation.

Using the SEER database, we ascertained the incidence rate, 5-year survival by disease stage at diagnosis, and 5-year conditional survival after surviving for 1-3 years for cases recorded between 1973 and 2005. We stratified the incidence rate by race and histology to examine if these factors affect disease characteristics.

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Penn Medicine - Penn researchers discover genetic risk factor for testicular cancer
June 2, 2009
Source: University of Pennsylvania School of Medicine / University of Pennsylvania Health System

PHILADELPHIA – Researchers at the University of Pennsylvania School of Medicine have uncovered variation around two genes that are associated with an increased risk of testicular cancer. Testicular cancer is the most common cancer among young men, and its incidence among non-Hispanic Caucasian men has doubled in the last 40 years -- it now affects seven out of 100,000 white men in the United States each year. The discovery, published in the May 31, 2009 online issue of Nature Genetics, is the first step toward understanding which men are at high risk of disease.

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UroToday - Maternal smoking, alcohol, and coffee use during pregnancy and son's risk of testicular cancer
June 1, 2009
Source: UroToday

It has been suggested that increased risk for testicular cancer occurring worldwide may be due to exposures during fetal development. Lifestyle or environmental exposures may be the most important predictors of risk. However, few studies have directly examined these exposures prospectively. The Child Health and Development Studies is a 40-year follow-up of 20,530 pregnancies occurring between 1959 and 1967.

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Mail Online - Scientists pinpoint faulty genes in new hope for testicular cancer test.
June 1, 2009
By Fiona Macrae

Genes behind testicular cancer have been pinpointed for the first time, paving the way for a test to identify those at high risk of developing the disease.

Scientists already knew that men with a close relative with the cancer are more likely to get it themselves.

But the breakthrough will hasten the development of a screening programme that could improve rates of early detection and prevention.

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Science Daily - Genetic risk factor for testicular cancer discovered: Gene is associated with a three-fold increase in risk
June 1, 2009
Source: Science Daily

ScienceDaily (June 1, 2009) — Researchers at the University of Pennsylvania School of Medicine have uncovered variation around two genes that are associated with an increased risk of testicular cancer. Testicular cancer is the most common cancer among young men, and its incidence among non
-Hispanic Caucasian men has doubled in the last 40 years -- it now affects seven out of 100,000 white men in the United States each year. The discovery, published in the May 31, 2009 online issue of Nature Genetics, is the first step toward understanding which men are at high risk of disease.

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BBC News - Testicular cancer genetic advance
May 31, 2009
Source: BBC News

Researchers have for the first time found inherited genetic factors which raise the risk of testicular cancer.

A UK team found many testicular cancer patients shared common DNA variants on chromosomes five, six and 12 that healthy men did not have.

This finding was echoed in a separate US study in the same journal, Nature Genetics, which highlighted two of the same variations.

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February 23, 2009
By Michael Conlon; editing by Maggie Fox

CHICAGO (Reuters) - Infertile men are nearly three times more likely to develop testicular cancer than those who are fertile, U.S. researchers reported on Monday.

The finding suggests a common source for both problems, perhaps errors in the way the body tries to repair damage to genetic material or environmental factors, Dr. Thomas...

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Reuters - Marijuana may raise testicular cancer risk: study
February 9, 2009
By Will Dunham

WASHINGTON (Reuters) - Marijuana use may increase the risk of developing testicular cancer, in particular a more aggressive form of the disease, according to a U.S. study published on Monday.

The study of 369 Seattle-area men ages 18 to 44 with testicular cancer and 979 men in the same age bracket without the disease found that current marijuana users were 70 percent more likely to develop it compared to nonusers.

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Reuters - DDT-related chemical linked to testicular cancer
April 29, 2008
By Will Dunham

WASHINGTON, April 29 (Reuters) - A chemical that comes from the pesticide DDT may raise a man's risk of developing testicular cancer, U.S. researchers said on Tuesday.

They found a clear link between testicular cancer and DDE, which is created when the body or the environment breaks down the pesticide DDT.

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